Voltage - gating by Molecular Subunits of Na + and K + Ion - channels ; 5 Higher - dimensional Cubic Kinetics , Rate Constants , and Temperature

1 2 3 4 Voltage-gating by Molecular Subunits of Na+ and K+ Ion-channels; 5 Higher-dimensional Cubic Kinetics, Rate Constants, and Temperature 6 7 8 Jürgen F. Fohlmeister 9 10 Department of Integrative Biology and Physiology 11 and 12 Graduate Program in Neuroscience 13 14 University of Minnesota 15 Minneapolis, Minnesota 55455 16 17 18 19 20 21 Running Title: Voltage-gating by Channel-molecular Subunits 22 23 24 25 26 Contact Information: Dr. J. F. Fohlmeister 27 Department of Integrative Biology and Physiology 28 6-125 Jackson Hall 29 321 Church street S.E. 30 University of Minnesota 31 Minneapolis, MN 55455 32 33 Phone: (612)-625-6958 34 FAX: (612)-625-5149 35 e-mail: [email protected] 36 37 38 39 40 41 42 ABSTRACT The structural similarity between the primary molecules of voltage-gated 43 Naand K-channels (Alpha subunits), and activation-gating in the Hodgkin-Huxley model, is 44 brought into full agreement by increasing the model's sodium-kinetics to fourth order (m3 → 45 Articles in PresS. J Neurophysiol (April 1, 2015). doi:10.1152/jn.00551.2014